[Download] "Determinants of Increased Plasma Homocysteine in 221 Stable Liver Transplant Patients (Technical Briefs)" by Clinical Chemistry # eBook PDF Kindle ePub Free

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eBook details

• Title: Determinants of Increased Plasma Homocysteine in 221 Stable Liver Transplant Patients (Technical Briefs)
• Author : Clinical Chemistry
• Release Date : January 01, 2001
• Genre: Chemistry,Books,Science & Nature,
• Pages : * pages
• Size : 188 KB

Description

The plasma homocysteine concentration (tHcy) is affected by genetic and physiologic determinants, by life-style (including nutritional deficiencies of vitamins [B.sub.6], [B.sub.12], and folate), diseases, and by some drugs (1-4). Moderately increased tHcy is considered an independent risk factor for atherosclerotic disease in the coronary, cerebral, and peripheral arteries (1, 2) and a significant predictor of mortality in patients with coronary disease (5, 6). In renal and cardiac transplant recipients, tHcy is markedly increased and is associated with impaired renal function (7-12) and with low serum folate in some series (8-11). Some studies (7,10), but not others (8, 11,12), have reported that cyclosporine treatment and whole blood cyclosporine concentration were determinants of tHcy in renal and cardiac transplant recipients. Data on tHcy in liver transplant recipients are limited, and increased tHcy has been associated with renal dysfunction but not with folate concentrations or cyclosporine therapy (13). Our aims were to evaluate the prevalence of increased tHcy and factors that affect tHcy in liver transplant patients.

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